The John D. and Catherine T. MacArthur Foundation is a private, independent grantmaking institution dedicated to helping groups and individuals foster lasting improvement in the human condition. The Foundation seeks the development of healthy individuals and effective communities; peace within and among nations; responsible choices about human reproduction; and a global ecosystem capable of supporting healthy human societies. The Foundation pursues this mission by supporting research, policy development, dissemination, education and training, and practice.

The MacArthur Foundation is a non-profit charitable corporation based in Chicago, Illinois. The MacArthur Foundation has a long standing interest in mental health research, and the Foundation's directors view primary care physicians as central to care for depression.

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